📊 50% of U.S. Jobs Aren't Using AI Yet

Welcome to Guru99 AI Report!

Together With 👉 NinjaOne 👈

Top Story: AI headlines are everywhere, yet real-world adoption tells a more nuanced story. Inside, we unpack new data, emerging shifts, and the quiet changes shaping how work, innovation, and opportunity are evolving right now.

🚀 AI at Work Is Taking Off - But Half of Workers Are Sitting It Out

Brief Buzz: A new Gallup AI in the Workplace report (Q4 2025) suggests workplace AI adoption is no longer accelerating - it's leveling off. While power users are going deeper, nearly half of U.S. workers still don't touch AI at all, widening the gap between AI "haves" and "have-nots." You can read the full findings in Gallup's AI in the Workplace report.

• Nearly 50% of American workers never use AI tools at work
• Tech leads adoption (60% frequent use), but growth is starting to stall
• Remote-capable roles dominate: 66% use AI vs. 32% in on-site jobs
• Leaders outpace employees (69% vs. 40%), citing "lack of clear utility" as the top blocker
• Retail and manufacturing lag far behind, increasing workforce inequality

Why Should You Care?

This isn't just about tools - it's about career acceleration. AI is quietly becoming a multiplier for productivity, pay, and influence, but only for those using it. As adoption stalls, early and strategic users gain a compounding advantage, while others risk falling behind. The gap won't close on its own - and competition is about to get much fiercer.

👉 In partnership with NinjaOne

NinjaOne harnesses artificial intelligence to simplify endpoint management, patching, and overall IT operations. Its AI stack focuses on turning the flood of patch data and device telemetry into precise, actionable guidance for busy IT teams. One flagship capability is Patch Intelligence AI, which applies generative-AI–powered sentiment analysis to Microsoft KB updates and other patches, ranking each update’s stability based on global telemetry and community feedback so you can pre-empt incompatible or risky fixes before they hit production.

Beyond individual patches, NinjaOne feeds that same AI signal into a risk-based vulnerability workflow. By blending CVE/CVSS scores with its AI-driven patch sentiment, the platform automatically surfaces the vulnerabilities most likely to compromise your estate, trims noise, and proposes the fastest remediation path - all from a single console.

• Patch Intelligence AI: Generative-AI sentiment analysis highlights unstable Windows and third-party patches and recommends delay or sandbox testing.
• Predictive Endpoint Analytics: ML models detect anomalies early and launch policy-based remediation to prevent downtime.

🧠 Nvidia Launches AI Effort Aimed at Thousands of Untreatable Diseases

Brief Buzz: A new AI-powered gene therapy approach promises to go beyond tiny DNA edits and instead replace genes precisely, a long-standing goal in medicine. Nvidia has partnered with UK startup Basecamp Research to unveil AI-Programmable Gene Insertion (aiPGI) — a potential leap toward curing previously untreatable diseases, according to Basecamp's press release.

• Programmable gene insertion lets scientists swap out entire faulty genes at precise genome sites
• Powered by Nvidia's EDEN AI models, designed for DNA and biology via the BioNeMo platform
• Lab results — including work with Microsoft — show successful insertions at disease-relevant human targets
• Basecamp demonstrated effectiveness across 10,000+ disease-linked genome locations and on cancer cells
• Nvidia's NVentures investment is backing faster development of these therapies

For scientists and developers, Basecamp's thorough EDEN model technical brief is available in the full report.

Why Should You Care?

If this AI-designed insertion technique works safely in people, we could shift from treatments that manage symptoms to therapies that fix genes permanently — offering real cures for cancers and rare inherited diseases. This development reinforces the long-forecasted promise of AI in genomics highlighted by ARK Invest in its Genomic Revolution strategy and recent newsletter insights.

It could also help revive funding for gene therapy research after years of widening funding gaps in life sciences and drug development.

👉 Speed Your Windows PC

⚡️ 5 AI Tools to Supercharge Your Productivity

👉 ActivTrak - AI-powered workforce-analytics engine auto-classifies every app & website activity to reveal focus vs distraction trends and productivity baselines. Predictive coaching dashboards surface "nudges" for managers, using ML to flag at-risk teams and recommend schedule or workload tweaks.

👉 Teramind - delivers a comprehensive suite for insider threat prevention and employee monitoring. It enhances security through behavior analytics and data loss prevention, ensuring compliance and optimizing business processes.

👉 Human Interest - The platform uses AI-driven compliance intelligence to continuously monitor regulatory requirements, automatically flag anomalies, and reduce the administrative burden associated with plan oversight.

👉 RemotePC is a remote access solution that allows users to connect and control computers from any location. Its AI-driven features include automatic session optimization, providing seamless performance by adjusting to network conditions.

👉 Campaign Monitor - This email-marketing platform includes an AI-Writer tool that enables users to generate campaign copy, headlines and CTAs with minimal effort; you can prompt it to brainstorm, refine tone of voice, or shorten long text into punchy blurbs.

🛠️ How A16Z's Mega-Fund Is Redefining the Future of VC

Brief Buzz: A single venture fund just swallowed a massive slice of last year's startup money. According to Forbes, Andreessen Horowitz (a16z) deployed its $15B Growth Fund, capturing nearly 20% of all U.S. venture capital raised — an unprecedented level of concentration that's quietly rewriting how startups get funded.

• One fund, outsized power: a16z's Growth Fund alone rivaled entire VC markets
• Late-stage dominance: capital flowed heavily into fewer, larger bets
• AI at the center: much of the spending targeted AI and infrastructure plays
• Smaller VCs squeezed: fewer dollars left for early-stage and niche funds

Why Should You Care?

When one firm controls a fifth of venture dollars, innovation risks becoming less diverse and more centralized. For founders, it means harder competition for funding unless you fit a narrow "big-winner" profile. For everyone else, it shapes which AI tools, platforms, and startups actually reach the market — and which never get the chance.

In short: the future of tech may be decided by fewer checks, written by fewer hands.

🔥 Darren Aronofsky Unleashes a Bold AI Take on the Revolutionary War

Brief Buzz: A new short-form series is using AI-powered visuals to bring the American Revolution to life — released exactly 250 years after each event happened. Led by filmmaker Darren Aronofsky, the project blends cutting-edge AI with human performers, signaling a shift in how Hollywood experiments with AI storytelling.

• "On This Day… 1776" is produced by Aronofsky's AI venture Primordial Soup, using tools from Google DeepMind (more on the DeepMind–Primordial Soup collaboration)
• Episodes debut on TIME's YouTube channel, timed to real historical anniversaries — watch the first episode here
• Visuals are AI-generated, but SAG-AFTRA voice actors keep humans at the center
• Follows Aronofsky's Veo-assisted short ANCESTRA, premiered at the Tribeca Film Festival (see the behind-the-scenes look)

Why Should You Care?

This marks AI's shift from experimental demos to real studio pipelines. If this approach scales, expect faster historical storytelling, lower production barriers, and renewed debates around creative ownership, labor, and how much of Hollywood's future is human-led versus machine-assisted.

🌍 Google Unveils Project Genie, Turning Ideas Into Interactive Worlds

Brief Buzz: Google is pushing AI beyond chat and images into interactive virtual worlds. Its new experimental tool, Project Genie, lets users create, explore, and remix living environments — hinting at how AI could one day understand and navigate reality itself, not just describe it.

• Google launched Project Genie, a world-building AI prototype for U.S. AI Ultra subscribers
• Powered by Gemini, Nano Banana Pro, and Genie 3, its most advanced world model yet
• Users can sketch worlds, explore them in real time, and remix existing environments
• Still experimental: worlds may break physics rules, run only 60 seconds, and offer limited character control
• Part of Google's AGI push, as world models attract massive funding interest — from Fei-Fei Li's World Labs (see Bloomberg's report on its $5B valuation talks) to global AI startups tracked by DigiTimes

Why Should You Care?

Because world models could change how AI learns. Instead of just predicting text, AI can test actions, consequences, and physics — something critics of "just scale it" AI argue is essential (see Gary Marcus on why scale isn't enough). This tech could unlock smarter games, safer simulations, and real-world systems — especially when paired with Google's push into physical AI, like Gemini Robotics.

👉 Turn Concepts to Flowcharts Instantly

🧠 How to Build a Competitor Database That Actually Helps You

This guide walks you through how to set up a competitor intelligence database powered by Claude Cowork. The best part? It essentially builds itself. All you need to do is download the prompt files, ask Claude to handle the setup, and you'll be up and running in about 5 minutes.

Step-by-step

1. Grab the free prompt files, save them in a new folder, and then select that folder by navigating to the "Cowork tab" in the Claude desktop app (Mac only).
2. Tell Claude to read the SOP and set up your directory. This step should take about 2–3 minutes to complete.
3. To test everything, give Claude [competitor name] + [website link]. Claude will automatically generate a report called a "killsheet" and file it away in your database.
4. Run a new killsheet generationeach quarter and after big competitor news to keep your intelligence fresh and up to date.

💡 Pro Tip: Once your database has a few killsheets, ask Claude to identify patterns and trends across competitors — this makes it much easier to spot strategic gaps and opportunities before your competitors do.

👉 Ultimate Note App Comparison Guide

📸 AI Generator Images: Surreal Art

Midjourney Prompt: surreal photograph inspired by Salvador Dalí, featuring symbolic representation of Marlin Monroe, Monroe's melting head dissolves into dreamlike desert landscape, one eye replaced with a dripping pocket watch, her hair is transforming into clouds. Brain-shaped stones lie in the sand, a pink Flamingo appears in the sky, stairs lead to nowhere, long shadows cast across the surreal plain. Soft lighting, hyperrealistic textures, uncanny atmosphere, psychological undertones, subtle references to psychoanalysis and dreams. Shot on ARRI ALEXA 65, 50mm, 400 iso, 8k, Best quality --ar 9:16 --v 7